E-submission
Search
- Page Path
- HOME > Search
Original Articles
- PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
- Ji Hyun Lee, Hye Ju Kang, Chong Woo Yoo, Weon Seo Park, Jun Sun Ryu, Yuh-Seog Jung, Sung Weon Choi, Joo Yong Park, Nayoung Han
- J Pathol Transl Med. 2019;53(1):23-30. Published online November 14, 2018
- DOI: https://doi.org/10.4132/jptm.2018.10.12
- 7,856 View
- 336 Download
- 23 Web of Science
- 26 Crossref
-
Abstract
PDF - Background
Recent findings in molecular pathology suggest that genetic translocation and/oroverexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. Weinvestigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues.
Methods
A total of 113 cases of surgically resected salivary gland neoplasms at the NationalCancer Center from January 2007 to March 2017 were identified. Immunohistochemical stainingof PLAG1, SOX10, and Myb in tissue samples was performed using tissue microarrays.
Results
Among the 113 cases, 82 (72.6%) were benign and 31 (27.4%) were malignant. PLAG1 showednuclear staining and normal parotid gland was not stained. Among 48 cases of pleomorphicadenoma, 29 (60.4%) were positive for PLAG1. All other benign and malignant salivary glandneoplasms were PLAG1-negative. SOX10 showed nuclear staining. In normal salivary gland tissuesSOX10 was expressed in cells of acinus and intercalated ducts. In benign tumors, SOX10 expressionwas observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not inother benign tumors. SOX10 positivity was observed in nine of 31 (29.0%) malignant tumors.Myb showed nuclear staining but was not detected in normal parotid glands. Four of 31 (12.9%)malignant tumors showed Myb positivity: three adenoid cystic carcinomas (AdCC) and onemyoepithelial carcinoma with focal AdCC-like histology.
Conclusions
PLAG1 expression is specificto pleomorphic adenoma. SOX10 expression is helpful to rule out excretory duct origin tumor,but its diagnostic value is relatively low. Myb is useful for diagnosing AdCC when histology isunclear in the surgical specimen. -
Citations
Citations to this article as recorded by
- Immunohistochemical Characterization of a Large Cohort of Triple Negative Breast Cancer
Rachel Han, Sharon Nofech-Mozes, Dina Boles, Hannah Wu, Nikolina Curcin, Elzbieta Slodkowska
International Journal of Surgical Pathology.2024; 32(2): 239. CrossRef - Proceedings of the 2024 North American Society of Head and Neck Pathology Companion Meeting, Baltimore, MD, March 24, 2024: Navigating Ancillary Studies in Basaloid/Blue Salivary Tumors
Kristine S. Wong
Head and Neck Pathology.2024;[Epub] CrossRef - The Challenge of “Monomorphic” Mucoepidermoid Carcinoma—Report of a Rare Case with Pure Spindle-Clear Cell Morphology
Xinyi Qu, Edwin Jun Chen Chew, Sathiyamoorthy Selvarajan, Bingcheng Wu, Abbas Agaimy, Fredrik Petersson
Head and Neck Pathology.2023; 17(3): 864. CrossRef - SOX10
Albert L Sy, Mai P Hoang
Journal of Clinical Pathology.2023; 76(10): 649. CrossRef - Activating Transcription Factor 1 (ATF1) Immunohistochemical Marker Distinguishes HCCC from MEC
Wafaey Badawy, Asmaa S. Abdelfattah, Haneen A. Sallam
Journal of Molecular Pathology.2023; 4(3): 178. CrossRef - Rare case of pleomorphic adenoma presenting as peritonsilar tumor
Anđelina Jovanović, Svetlana Valjarević, Milan Jovanović
Medicinska istrazivanja.2023; 56(3): 95. CrossRef - Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate: A Case Report
Ishank Panchal, Anil Wanjari
Cureus.2023;[Epub] CrossRef - Advanced Diagnostic Methods for Salivary Glands Diseases: A Narrative Review Study
Malak Mohammed AlOsaimi, Abdulaziz Mohammed AlSubaheen, Taif Saleh Jameel, Rand Abdulrahman AlSalamah, Dalal Naseh AlAnzi, Norah Ameen AlOushan, Fahad Fadhel AlShammari, Cristalle Soman
Clinical Cancer Investigation Journal.2023; 12(4): 19. CrossRef - Clinical Significance of SOX10 Expression in Human Pathology
Hisham F. Bahmad, Aran Thiravialingam, Karthik Sriganeshan, Jeffrey Gonzalez, Veronica Alvarez, Stephanie Ocejo, Alvaro R. Abreu, Rima Avellan, Alejandro H. Arzola, Sana Hachem, Robert Poppiti
Current Issues in Molecular Biology.2023; 45(12): 10131. CrossRef - NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens
Kartik Viswanathan, Shaham Beg, Bing He, Taotao Zhang, Richard Cantley, Daniel J Lubin, Qiuying Shi, Zahra Maleki, Saeed Asiry, Rema Rao, Nora Katabi, Masato Nakaguro, William C Faquin, Peter M Sadow, Momin T Siddiqui, Theresa Scognamiglio
American Journal of Clinical Pathology.2022; 157(1): 98. CrossRef - Recent Advances on Immunohistochemistry and Molecular Biology for the Diagnosis of Adnexal Sweat Gland Tumors
Nicolas Macagno, Pierre Sohier, Thibault Kervarrec, Daniel Pissaloux, Marie-Laure Jullie, Bernard Cribier, Maxime Battistella
Cancers.2022; 14(3): 476. CrossRef - Diagnostic accuracy of human transcriptional activator (Myb) expression by ELISA technique versus immunohistochemistry in detecting salivary gland carcinomas
Yousra Refaey, OlfatGamil Shaker, Ayman Abdelwahab, ImanAdel Mohamed Abdelmoneim, Fat’heyaMohamed Zahran
Journal of International Oral Health.2022; 14(1): 61. CrossRef - SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma
Hyesung Kim, Seung Bum Lee, Jae Kyung Myung, Jeong Hwan Park, Eunsun Park, Dong Il Kim, Cheol Lee, Younghoon Kim, Chul-Min Park, Min Bum Kim, Gil Chai Lim, Bogun Jang
Laboratory Investigation.2022; 102(6): 631. CrossRef - Assessment of MEF2C as a novel myoepithelial marker using normal salivary gland and pleomorphic adenoma: An immunohistochemical study
Ikuko Takakura, Satoko Kujiraoka, Rika Yasuhara, Junichi Tanaka, Fumio Ide, Kenji Mishima
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2022; 34(4): 523. CrossRef - Update on selective special types of breast neoplasms: Focusing on controversies, differential diagnosis, and molecular genetic advances
Shi Wei
Seminars in Diagnostic Pathology.2022; 39(5): 367. CrossRef - Cutaneous Melanomas: A Single Center Experience on the Usage of Immunohistochemistry Applied for the Diagnosis
Costantino Ricci, Emi Dika, Francesca Ambrosi, Martina Lambertini, Giulia Veronesi, Corti Barbara
International Journal of Molecular Sciences.2022; 23(11): 5911. CrossRef - Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast
Juan Ji, Fang Zhang, Fanglei Duan, Hong Yang, Jun Hou, Yang Liu, Jie Dai, Qiong Liao, Xian Chen, Qingsong Liu
Scientific Reports.2022;[Epub] CrossRef - NR4A3 fluorescence in situ hybridization analysis in cytologic and surgical specimens of acinic cell carcinoma
Qiuying Shi, Bin Zhang, Caroline Bsirini, Liqiong Li, Ellen J. Giampoli, Kelly R. Magliocca, Michelle Reid, Zhongren Zhou
Human Pathology.2022; 127: 86. CrossRef - Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma
John M. Skaugen, Raja R. Seethala, Simion I. Chiosea, Michael S. Landau
Cancer Cytopathology.2021; 129(2): 104. CrossRef -
MYB-NFIB Translocation by FISH in Adenoid Cystic Carcinoma of the Head and Neck in Nigerian Patients: A Preliminary Report
Adepitan A. Owosho, Olufunlola M. Adesina, Oluwole Odujoko, Olujide O. Soyele, Akinwumi Komolafe, Robert Bauer, Kallie Holte, Kurt F. Summersgill
Head and Neck Pathology.2021; 15(2): 433. CrossRef - Liquid-based cytology of oral brushings in a case of adenoid cystic carcinoma arising from the palate
Ryo MAKINO, Akihiko KAWAHARA, Hideyuki ABE, Yorihiko TAKASE, Chihiro FUKUMITSU, Kazuya MURATA, Tomoko YOSHIDA, Yukako SHINODA, Yoshiki NAITO, Jun AKIBA
The Journal of the Japanese Society of Clinical Cytology.2021; 60(1): 33. CrossRef - MYB Translocations in Both Myoepithelial and Ductoglandular Epithelial Cells in Adenoid Cystic Carcinoma: A Histopathologic and Genetic Reappraisal in Six Primary Cutaneous Cases
Keisuke Goto, Kazuyoshi Kajimoto, Takashi Sugino, Shin-ichi Nakatsuka, Makoto Yoshida, Mai Noto, Michihiro Kono, Toshihiro Takai
The American Journal of Dermatopathology.2021; 43(4): 278. CrossRef - Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma
Costantino Ricci, Federico Chiarucci, Francesca Ambrosi, Tiziana Balbi, Barbara Corti, Ottavio Piccin, Ernesto Pasquini, Maria Pia Foschini
Head and Neck Pathology.2021; 15(4): 1385. CrossRef - Juvenile onset pleomorphic adenoma presenting as giant tumor of parotid gland in a young female
Surender Verma, Shivika Aggarwal, Pradeep Garg, Anjali Verma, Mridul Gera, SwaranS Yadav
Journal of Dr. NTR University of Health Sciences.2021; 10(4): 286. CrossRef - Cytopathology and diagnostics of Warthin's tumour
Mirna Sučić, Nives Ljubić, Leila Perković, Dunja Ivanović, Leo Pažanin, Tena Sučić Radovanović, Dubravka Župnić‐Krmek, Fabijan Knežević
Cytopathology.2020; 31(3): 193. CrossRef - Clear cell papillary neoplasm of the breast with MAML2 gene rearrangement: Clear cell hidradenoma or low-grade mucoepidermoid carcinoma?
Raima A. Memon, Carlos N Prieto Granada, Shi Wei
Pathology - Research and Practice.2020; 216(10): 153140. CrossRef
- Immunohistochemical Characterization of a Large Cohort of Triple Negative Breast Cancer
- Expression of p53 Protein and Ki-67 in Atypical Ductal Hyperplasia, Ductal Carcinoma in Situ, and Microinvasive Ductal Carcinoma of the Breast.
- Yi Kyeong Chun, Hye Sun Kim, Yee Jeong Kim, Sung Ran Hong, Hy Sook Kim, Byung Jun Park, Sung Su Kang, Ji Hyun Lee, Sung Kong Lee, Sun Hee Sung, Woon Sup Han
- Korean J Pathol. 2000;34(9):665-672.
- 1,891 View
- 19 Download
-
Abstract
PDF
- Mutation of the p53 gene is one of the most common genetic alterations in invasive breast carcinoma. However, it is unclear that the mutation usually occurs in noninvasive breast lesions. It might be expected that there is a correlation between histologic progression of breast lesions and proliferative rate. We investigated the expression of p53 protein and Ki-67 labelling index (LI) using immunohistochemistry in 16 ductal carcinoma in situ with microinvasion (DCIS-Mi), 56 DCIS, 15 atypical ductal hyperplasia (ADH), and 7 intraductal hyperplasia (IDH). Expression of p53 protein was detected in 33.9% of DCIS and 56.3% of DCIS-Mi and was confined exclusively in Van Nuys DCIS group 2 and 3. In ADH and IDH, no expression of p53 protein was found. There was no significant correlation between Van Nuys DCIS groups and Ki-67 LI. In conclusion, p53 mutation may be involved in the neoplastic progression from ADH to DCIS and is directly related to high nuclear grade and associated necrosis of DCIS.
- Usefulness of Frozen Section Examination of Core Needle Biopsy in the Breast Carcinoma.
- Yee Jeong Kim, Yi Kyeong Chun, Sung Ran Hong, Hy Sook Kim, Sung Su Kang, Ji Hyun Lee, Sung Kong Lee, Hye Sun Kim
- Korean J Pathol. 2002;36(3):163-166.
- 1,555 View
- 15 Download
-
Abstract
PDF
- BACKGROUND
Core needle biopsy (CNB) is widely used as the initial sampling method for breast cancer. And because frozen section (FS) diagnosis is rapid and reliable, we studied the diagnostic agreement between the diagnosis of FS of CNB and final diagnosis after surgery to evaluate the diagnostic accuracy of the FS of CNB.
METHODS
Of 409 patients who were preoperatively diagnosed by FS of CNB and who underwent final surgery from 1996 through 2000, 24 cases were found to be ductal carcinoma in situ (DCIS) and 385 cases invasive carcinoma (IC). The diagnoses of FS of CNB were compared with final diagnoses.
RESULTS
The diagnostic accuracy of carcinoma is 63.6% for DCIS and 86.9% for invasive carcinoma. Five cases (1.2%) could not be diagnosed because of material insufficiency for diagnosis. Twenty two cases (5.4%) were diagnosed as benign on FS, among which 20 (90.9%) were misdiagnosed by sampling error. Twenty seven cases (6.7%) were deferred on FS, 4 of these cases were DCIS, 5 were invasive lobular carcinoma (ILC), the rest displayed low nuclear grades or marked freezing artifacts.
CONCLUSIONS
The diagnostic accuracy of FS of CNB is very high except for cases of ILC and low grade DCIS. Considering the advantage of rapid evaluation, more definitive diagnosis, familiarity by pathologists and availability of ancillary study, FS of CNB is very useful method as the preoperative evaluation.
First
Prev
